San Antonio’s commercial real estate market is thriving, with expansion across retail, industrial, and medical sectors. Investors and business owners are flocking to key areas, including Downtown, the Medical Center, and Alamo Ranch, to capitalize on high demand and economic growth.

Whether you’re looking to invest in San Antonio’s commercial real estate, open a business, or lease office space, this blog will walk you through the top areas and properties to watch in 2025.

San Antonio’s economic growth, population boom, and business-friendly climate make it one of the top cities for commercial investment in Texas.

Key Factors Driving Growth

✔️ Strong Population Growth – Over 1.69% annual increase
✔️ Job Market Expansion – Unemployment at 3.6% (lower than national average)
✔️ Retail & Industrial Demand – Vacancy rates at 4% or lower
✔️ Business Incentives – Tax-friendly policies and opportunity zones

Let’s dive into San Antonio’s top commercial real estate markets, broken down by location.

Key Areas: Potranco Road, Highway 151, Westover Hills

• Retail Boom – Big brands like Burlington and H-E-B expanding
• Industrial Growth – Warehouse and logistics spaces in high demand
• Housing Surge – Increased population growth driving business expansion

Development to Watch:

• Alamo Ranch Marketplace Expansion – More retail and dining options
• Westover Hills Business Park – Corporate office and industrial space

Why Invest? Affordable commercial space and rapidly growing residential areas make West San Antonio a top investment choice.

Key Areas: Pearl District, Southtown, St. Mary’s Strip

• High Demand for Office & Retail Space
• Tourism & Hospitality Growth – Driven by the River Walk and Alamo renovations
• Luxury High-Rises & Mixed-Use Developments

Development to Watch:

• Frost Tower Area Expansions – New office space & retail
• Southtown Boutique Hotels – New investment opportunities

Why Invest? Premium locations for restaurants, tech offices, and luxury retail.

Key Areas: Alamo Ranch, Government Canyon, Culebra Road

• Fastest-Growing Suburb in San Antonio
• New Retail Developments – H-E-B, Costco, and entertainment centers
• High Demand for Medical & Office Spaces

Development to Watch:

• Alamo Ranch Pavilion – Expanding grocery-anchored retail centers

Why Invest? Low vacancy rates and strong rental demand for commercial properties.

Key Areas: Loop 1604 & Highway 281, Sonterra Boulevard

• Major Medical Hub – Hospitals & specialist centers
• Luxury Office & Retail Spaces – High-income clientele
• Corporate Expansions & Tech Growth

Development to Watch:

• Stone Oak Medical Pavilion – New healthcare facilities
• Sonterra Boulevard Mixed-Use – Office & high-end retail

Why Invest? Affluent population, premium office space, and medical growth.

Key Areas: AT&T Center, St. Paul Square, East Houston Street

• Ongoing Revitalization & City Investments
• Mixed-Use Developments – Office, retail, and apartments
• Industrial & Logistics Demand – Proximity to I-10 & I-35

Development to Watch:

• Essex Modern City – Transforming the East Side with mixed-use projects
• New Brewery & Restaurant District

Why Invest? Emerging market with high ROI potential and affordable properties.

Key Areas: Brooks City Base, Palo Alto, Loop 410

• Affordable Commercial Property with High Growth Potential
• New Healthcare & University Expansions
• Logistics & Warehousing Opportunities

Development to Watch:

• Methodist Healthcare South Side Expansion – New hospital development
• Brooks City Base Business Park – Tech & logistics hub

Why Invest? Lower property costs and increasing demand for services.

Key Areas: Boerne, Bulverde, Fair Oaks Ranch

• Luxury Retail & Office Growth
• Warehouse & Industrial Demand – Expansion along I-10
• Tech & Business Development

Development to Watch:

• Boerne Town Center Expansion – High-end retail & offices
• New Industrial Parks Along I-10

Why Invest? High-income demographics and business-friendly environment.

Key Areas: Medical Drive, Wurzbach Road, UTSA Boulevard

• San Antonio’s Premier Healthcare District
• Tech & Startup Growth near UTSA
• Medical Office Space Demand

Development to Watch:

• Medical Center Tower Expansion – More office space for healthcare providers
• UTSA Innovation Park – Boosting San Antonio’s tech sector

Why Invest? Steady rental demand and future appreciation.

Key Areas: I-35 Corridor, Creekside Town Center

• Retail & Business Expansion Along I-35
• Fast-Growing Residential Markets
• Industrial & Manufacturing Growth

Development to Watch:

• New Braunfels Tech Park – Emerging as a business hub
• Schertz Gateway Center – Mixed-use development

Why Invest? Booming residential areas driving commercial demand.

Key Areas: Bandera Road, Loop 410 & 1604

• Growing Retail & Restaurant District
• New Medical Facilities & Office Spaces
• Affordable Commercial Space with High Traffic

Development to Watch:

• Leon Valley Medical Plaza – New healthcare complex
• Northwest Crossing Retail Center – Expanding shopping & dining options

Why Invest? Affordable commercial property with excellent growth potential.

Navigating the San Antonio real estate market, especially when looking for eco-friendly options, requires expertise and up-to-date information. My name is Anna Ghalumian, and together with my incredible team at the True North Group, we’re here to guide you through every step of the process.

Whether you’re relocating in 7 days or 77 days, we’ll help you find the perfect home that fits your lifestyle and sustainability goals. Book a call today for a personalized consultation and let us help you discover San Antonio’s best commercial properties.